Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city

نویسندگان

چکیده

Coronavirus infection a new infectious illness brought on by the SARS-COV-2 virus has infected people worldwide as of 2019, covid-19 disease is associated with hematological and biochemical parameters changes. The present study aimed to evaluate possible relationship between patient severity. A total 200 nasopharyngeal swabs whole blood specimens were collected from individuals suspected CoV-2 healthy volunteers control both sexes, grouped into four groups:50 patients for each mild, moderate, severe 50 volunteers. current demonstrated that female 82(55%) was more frequently affected than male 68(45%). Hematological including white cell count (WBC), granulocyte count, Red distribution width (RDW%) (increased significantly p < 0.05, while Lymphocyte decreased when compared group. Significant differences in hemoglobin concentration, packed volume, red indices shown group sexes. Regarding serum vitamin D, ferritin, D-dimer, procalcitonin (PCT), liver function tests, D significantly, enzymes increased According receptor ,gene polymorphism genotype Bb most likely strongly related getting all three known stages infection.Severity leukocytosis, lymphopenia biomarkers are best predictors CoV-2, strong relation VDR gene BsmI severity

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Association of Vitamin D Receptor Gene BsmI Polymorphism with Multiple Sclerosis in Iranian Patients

Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI polymorphism in vitamin D receptor gene (VDR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients w...

متن کامل

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

15 صفحه اول

Taq1 Polymorphism (rs731236) of Vitamin D Receptor Gene in Children with Acute Lymphoblastic Leukemia

Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Several studies have shown that ALL occurs as a result of genetic abnormalities. 1, 25-Dihydroxyvitamin D3 as a secosteroid hormone plays an important role in different metabolic pathways. The normal function of vitamin D occurs via binding to a ligand-activated transcription factor i.e. vitamin D receptor (VDR)...

متن کامل

Comparison of serum vitamin D levels in elderly patients with and without Covid-19

Background and purpose: due to the occurrence of covid-19 disease in the world and the lack of standard treatment for this disease, a lot of research was done to find the causes of the disease and the methods of treatment. and is not infected with covid 19. Materials and methods: This study is a case-control study and its statistical population was elderly people who referred to Bandargaz city...

متن کامل

Vitamin D receptor gene polymorphism in patients with sarcoidosis.

The active form of vitamin D, 1,25-dihydroxyvitamin D(3), is known to be produced at sites of granulomatous reactions in sarcoidosis. 1, 25-dihydroxyvitamin D(3) has multiple immunomodulatory effects, and acts as a promoter of multinucleated giant cell formation. Polymorphism of the vitamin D receptor (VDR) gene has recently been shown to be related to bone mineral density, and also associated ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Ma?alla? ??mi?a? kirk?k

سال: 2023

ISSN: ['1992-0849', '2616-6801']

DOI: https://doi.org/10.32894/kujss.2023.137833.1093